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KMID : 1007320070130010039
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Journal of the Korean Society of Menopause
2007 Volume.13 No. 1 p.39 ~ p.44
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Association between Serum Estradiol Level and Intraocular Pressure in Postmenopausal Women
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Park Sung-Kyun
Park Dae-Joong
Kim Ji-Sun
Koo Yun-Hee
Lee Sa-Ra
Kim Sung-Hoon
Chae Hee-Dong
Kim Chung-Hoon
Kang Byung-Moon
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Abstract
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Objectives: To evaluate the association between serum estradiol (E2) level and intraocular pressure (IOP) in postmenopausal women
Methods: From January 1999 to December 2000, serum concentration of estradiol and IOP were measured in 2,462 postmenopausal women. Serum concentration of estradiol was measured by radioimmunoassay and IOP was measured using Goldmann applanation tonometer. All data were analyzed using Student’s t-test, analysis of variance (ANOVA), and linear regression analysis.
Results: The mean age of the study subjects was 56.2±5.6 years. The mean E2 concentration was 13.4±12.9 pg/ml. The mean IOPs were 13.1±2.6 mmHg, 13.0±2.4 mmHg, and 13.0±2.6 mmHg for the left eyes, right eyes, and the average of both eyes, respectively. When the patients were divided into 2 groups or 4 groups according to the E2 concentration, the IOP of each group did not differ significantly. On linear regression analysis, no significant association was found between IOP and age or IOP and serum E2 concentration.
Conclusion: This study suggests that there is no direct association between IOP and serum E2 concentration in postmenopausal women.
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KEYWORD
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Serum estradiol concentration, Menopause, Intraocular pressure
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